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Bastiaan Driehuys and Tessa Sundarem Cook Young Investigator Award Finalist: Volunteer studies show agreement with plethysmography and MDCT.
However, an advantage of this technique is that it enables regional depiction of dynamic gas trapping in a setting more comparable to a spirometry maneuver, unlike MDCT. The protocol, validated on rats, was designed for single acquisition of multiple echo time ventilation images obtained at different inflation states of the lung.
Q-space data were fit to a Gaussian function providing maps of the mean structure size. The acquisition was also performed in a healthy volunteer at three inhalation volumes.
Structure size was observed to increase with lung volume.
In the lung parenchyma, these properties participate in the basic function of the organ. They are dramatically altered by diseases like cancer, emphysema, asthma, or interstitial fibrosis. Besides tactual exploration, there is no other non-invasive technique to assess such changes.
This work aims to produce a novel measurement tool based on magnetic resonance imaging of hyperpolarised helium-3 to monitor the mechanical properties of the lung, which allow mapping of its compliance and relating it to pathology.
We demonstrate its feasibility in vivo. Fully sampled 3D k-space data from one healthy subject and three COPD patients were undersampled and reconstructed by compressed sensing methods.
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We expect that the method can be used to either decrease scan time breath-hold or increase spatial resolution which will be especially important in longitudinal studies of lung disease progression.
Terekhov1, Julien Rivoire1, Florian M. Meise1, Davide Santoro1, Wolfgang G. The essential problem of efficiency of 3He-ADC-imaging as the diagnostic tool is the poor localisation of integrity defects due to low spatial resolution of ADC-maps.
The purpose of current work is to demonstrate the possibilities, provided by the phased-array parallel acquisition 32ch for improving the efficiency of 3He ADC-measurements including creating full-3D ADC-maps. The second important task is making comparison of different methods of reconstruction the undersampled imaging datasets e.
Dregely2, Stephen Ketel3, Iulian C. In this work we demonstrate the feasibility of obtaining gas-phase depolarization maps in humans using Xenon polarization Transfer Contrast XTC MRI by selectively inverting the magnetization in one of the two compartments. Preliminary results at 1.
These findings will considerably increase the specificity of XTC MRI for the detection of pathological lung function changes. The Fourier Decomposition method was implemented on a 1. A fast steady-state free precession SSFP pulse sequence was used to produce 2D time-resolved data stacks.
Non-rigid image registration and spectral analysis of the data allowed separating the signal from the lung parenchyma and pulsative blood to generate ventilation and perfusion maps.
The presented method requires only minimal patient compliance and is not dependent on triggering techniques. The utility of ultra-short TE UTE imaging in conjunction with projection acquisition of the free inducting decay helps to acquire the MR signal from the lung parenchyma.
Here we report our measure of short T2 relaxation time of the lung in the wild-type and emphysematous mice using three-dimensional UTE imaging.
Donahue2, Jinyuan Zhou1, James J. This arteriolar character was subsequently reflected in an effectively immediate hemodynamic response for iVASO when studying visual activation.
Claire Cohalan1, Jean J. Though the VASO technique is easier to implement, its signal potentially has many contributions other than CBV, and eliminating these contaminants is difficult, but necessary.This Article discusses Ivan Illich’s direction for social reform that led to his book, Tools for Conviviality, where Illich targeted development, technology, and the exploitation of nature.
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